Toronto Blue Jays starting pitcher Jose Berrios faces the Tampa Bay Rays during an MLB game at Rogers Centre in Toronto, Ontario.

The A's (23-33) and Toronto Blue Jays (27-28) begin a 4-game series Thursday. First pitch from Rogers Centre in Toronto is set for 7:07 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the A's vs. Blue Jays odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; tied 3-3 last season

The A's lost 5-3 to the Houston Astros on Wednesday as a +123 road underdog, with the game pushing on the 8-run total. Oakland was outscored 16-4 in their 2-game series against Houston, marking their 13th loss in the last 14 games.

The Blue Jays won 2-0 on Wednesday against the Texas Rangers, securing victory as a +118 road underdog and staying Under the 8.5-run total. Toronto's pitching staff allowed just 3 runs over the 3-game series in Arlington. However, they finished 2-4 on their 6-game road trip.

A's at Blue Jays projected starters

LHP Jacob Lopez vs. RHP Jose Berrios

Lopez (0-2, 2.57 ERA) is making his third start and sixth appearance. He has a 1.57 WHIP, 5.1 BB/9 and 10.9 K/9 in 14 innings.

  • Last start: Loss, 7 IP, 1 ER, 3 H, 1 BB, 8 K in 4-3 home defeat against the Philadelphia Phillies Friday
  • 2025 away stats: 0-1, 5.06 ERA (5 1/3 IP, 3 ER), 2.63 WHIP, 8.4 K/9 in 3 appearances (1 start)
  • Only start vs. Blue Jays: Win, 5 1/3 IP, 5 ER (6 R), 8 H, 2 BB, 4 K in 12-8 road victory Oct. 1, 2023, as a member of the Tampa Bay Rays

Berrios (1-2, 4.22 ERA) is making his 12th start. He has a 1.36 WHIP, 3.7 BB/9 and 7.9 K/9 in 64 innings.

  • Last start: Loss, 6 IP, 3 ER, 3 H, 1 BB, 3 K in 3-1 road loss against the Rays Saturday
  • 2025 home stats: 0-1, 5.19 ERA (34 2/3 IP, 20 ER), 1.47 WHIP, 8.3 K/9 in 6 starts
  • Career vs. A's: 3-3, 3.46 ERA (65 IP, 25 ER), 1.14 WHIP, 9.0 K/9 in 11 starts

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A's at Blue Jays odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:04 a.m. ET.

  • Moneyline (ML): A's +120 (bet $100 to win $120) | Blue Jays -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): A's +1.5 (-185) | Blue Jays -1.5 (+150)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

A's at Blue Jays picks and predictions

Prediction

Blue Jays 6, A's 2

Moneyline

PASS.

I'm jumping all over the Blue Jays (-145) on Thursday, but I'm going to take my wager to the plus odds on run line.

Run line/Against the spread

BET BLUE JAYS -1.5 (+150).

The Blue Jays are playing solid ball right now, even if they’re not quite elite, which still puts them well above the struggling A's. The A's have been on a downward spiral, going 7-18 in May, making it even tougher for them to keep up with Toronto’s ace. Berríos is 3-0 in his last 5 starts against the A's, never allowing more than 3 earned runs in those appearances. Though he has just 1 decision in his last 7 starts, Berríos has been strong, allowing only 2.4 earned runs per game during that stretch. The Blue Jays have won 4 of their last 5 games at Rogers Centre and 6 of the last 10 meetings against the A'thletics's, with 5 of those wins coming by 2 or more runs. Given their current form and Berríos’ dominance, the Blue Jays look poised to take advantage of the plus odds on Thursday.

Over/Under

PASS.

I do not like this number at all. The trends are basically 50/50 on the total bet. I'll stay away from this wager and keep my focus on the run line.

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This article originally appeared on Sportsbook Wire: A's at Toronto Blue Jays odds, picks and predictions

Reporting by Drew Phelps, Sportsbook Wire / Sportsbook Wire

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