A team at the University of Virginia (UVA) School of Medicine say that a key component of the immune system, the STING molecule, plays an important role in the development of both amyloid plaque and tau tangles in late-onset Alzheimer’s disease (AD). The research, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Foundation , provides a more detailed understanding of the immune system’s role in neurodegenerative diseases and an avenue for the development of new therapies to mediate the role STING plays in Alzheimer’s disease.

“Our findings demonstrate that the DNA damage that naturally accumulates during aging triggers STING-mediated brain inflammation and neuronal damage in Alzheimer’s disease,” said John Lukens, PhD, director of UVA’s Harrison Family Translationa

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