New research headed by a team at Lund University, Sweden, has identified three common gene variants that significantly raise the risk of venous thrombosis , a discovery the researchers contend is the most important genetic finding relating to blood clots since the discovery of Factor V Leiden. The study, published in the journal Research and Practice in Thrombosis and Haemostasis , showed that variants in the ABO, F8, and VWF genes can raise the risk of blood clots in the leg by up to 180%, and the team developed a risk scoring system based on this discovery. These variants were previously linked to plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF), both of which are known to influence the risk of venous thromboembolism (VTE).

The implications for cli

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