Russia sent waves of drones and missiles in an attack on the Ukrainian city of Odesa early Tuesday that killed at least two people, Ukraine officials said.

A maternity hospital and residential buildings in the center of the southern port city of Odesa were damaged in the attack, regional Gov. Oleh Kiper said.

Two people were killed and nine injured in the city, according to a statement from the regional prosecutor's office.

The fresh attacks came hours after Moscow launched almost 500 drones at Ukraine in the biggest overnight drone bombardment in the three-year war. Ukrainian and Western officials have been anticipating a Russian response to Ukraine's audacious June 1 drone attack on distant Russian air bases.