Key Takeaways

Sildenafil citrate did not improve perinatal outcomes compared with placebo in a trial with more than 3,000 patients.

Phosphodiesterase type 5 (PDE5) inhibitors like sildenafil citrate may prevent intrapartum fetal distress.

The results contradict an earlier study that indicated benefits with PDE5 inhibitors; further research is warranted.

Sildenafil citrate during labor did not improve perinatal outcomes potentially related to intrapartum hypoxia despite previous promising evidence, the multicenter iSEARCH trial of more than 3,000 patients found.

The primary composite outcome of infant mortality or neonatal morbidity occurred in 5.1% of the sildenafil citrate group and 5.2% of the placebo group (RR 1.02, 95% CI 0.75-1.37), reported Sailesh Kumar, DPhil (Oxon), of the Ma

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