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National Institutes of Health Director Dr. Jay Bhattacharya faced critical questions from both Republican and Democratic senators Tuesday as he sought to defend the Trump administration’s sweeping plans to reorganize the agency and slash budgets for medical research.

Senate Appropriations Chairwoman Susan Collins (R-ME) swiftly criticized the current budget cuts and proposed changes, including a nearly 40% reduction to the National Institute of Aging’s spending and 40% overall cuts to the agency’s institutes.

“As the senator representing … the oldest state in the nation, this is a particular concern,” Collins said. “I know personally what it means to so many American families.”

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