It was night sweats, wild mood swings, and, ironically, significant hair loss that first sent Kate, 54, a New York–based hairstylist, to her doctor in her late 40s looking for relief; she was prescribed an estrogen patch. “It made me feel like myself again,” says Kate, whose name has been changed to protect her privacy. “I was sleeping, I wasn’t losing my temper, and my mood really evened out, but I was still overweight.” Despite a healthy diet and regular exercise, there were a dozen or so pounds that just wouldn’t budge. So she started taking Wegovy . For Shelby Meade, 55, an LA-based publicist, regular doses of estrogen helped temper her sometimes 30-day periods but did nothing for her perpetually bloated state. “I was heavier than I’d ever been and there was a constant pressure o

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