The 2025 FedEx St. Jude Championship is set to tee off Thursday at 8:20 a.m. ET, which marks the beginning of the FedEx Cup Playoffs. The top 70 golfers are eligible for the first of three tournaments to claim the FedEx Cup trophy, as well as the $10 million bonus that comes with it, but Rory McIlroy opted out of the 2025 FedEx St. Jude Championship field. TPC Southwind in Memphis is the host site for the fourth straight year. World No. 1 Scottie Scheffler, who leads the FedEx Cup standings with 4,806 points, is the +280 favorite (risk $100 to win $280) in the 2025 FedEx St. Jude Championship odds ahead of Thursday's opening round.

Some of the other 2025 FedEx St. Jude Championship contenders include Xander Schauffele (18-1), Matthew Fitzpatrick (22-1), Justin Thomas (25-1), Tommy Fleetwo

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