The San Francisco 49ers have placed veteran wide receiver Equanimeous St. Brown on injured reserve (IR), effectively ending his 2025 season, per ESPN's Adam Schefter. St. Brown suffered a foot injury during a joint practice with the Denver Broncos on Thursday, prompting the move ahead of Week 1 of the preseason.

St. Brown, 28, stands at 6'5″ and weighs 214 pounds. The 49ers signed him on July 22, 2025 , released him briefly on July 31, and re-signed him on Tuesday . The 2025 season was set to be his seventh NFL season, having previously played for the Green Bay Packers, Chicago Bears, and New Orleans Saints. Over his six-year career, St. Brown has recorded 63 receptions for 928 yards and 2 touchdowns across 62 games, averaging 14.7 yards per catch on 110 targets.

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