Christian McCaffrey and Saquon Barkley will be two of the first running backs off the board in most 2025 Fantasy football drafts, even though they both have a history of missing games. In fact, they have combined for just six career top-five Fantasy finishes, so they could be 2025 Fantasy football busts to avoid. Ravens running back Derrick Henry has cracked the top five in five of the last six seasons, showcasing remarkable consistency. He is available later than McCaffrey and Barkley in some drafts, making him a potential Fantasy football sleeper.

Deciding how much risk you are willing to handle is one key to building a Fantasy football strategy. Which players should you target and avoid with your 2025 Fantasy football lineups? Whether you're hunting for a 2025 Fantasy football top 150

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