A study has found that prescribing semaglutide in everyday clinical settings led to modest but meaningful improvements in cardiovascular risk alongside a rise in non-drug healthcare costs.  The study, published Aug. 8 in JAMA Network Open, analyzed data from more than 23,500 adults across Yale New Haven (Conn.) Health System and Norfolk, Va.-based Sentara Healthcare. Researchers reported average reductions in body weight, blood pressure, total cholesterol and hemoglobin A1c. 

However, the benefits were smaller than those observed in a Step 1 clinical trial, which saw weight reductions near 15% at 12 months. Researchers attributed the discrepancy to factors such as adherence, with only 57.6% of patients maintaining active prescriptions past one year.  The study also found that healthcare s

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