Tampa Bay Rays pitcher Ryan Pepiot (44) in action against the Athletics at Sutter Health Park in West Sacramento, California.

The Tampa Bay Rays (61-63) and the San Francisco Giants (59-64) wrap up a 3-game interleague series Sunday at Oracle Park in San Francisco. First pitch is scheduled for 4:05 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the Rays vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Rays lead 2-0

The Rays have won a pair of 1-run games to open the series, and they're looking to complete the 3-game road sweep Sunday. The Rays cashed as an underdog (+100) Friday as the Over (8) cashed in a 7-6 win, while the Under (8) hit in a 2-1 win, cashing as a small favorite (-110).

In Saturday's game, Rays DH Yandy Diaz and 2B Brandon Lowe each went 2-for-4 with an RBI, while CF Jung Hoo Lee and 3B Christian Koss had multi-hit games for the Giants. Koss had the team's only extra-base hit, a double, while also driving in the team's only run.

Tampa Bay has won 3 games in a row, and 4 of the past 5 contests, all on the road. The Over is 5-2 in the past 7 games, too.

San Francisco has dropped 7 games in a row, and the offense has really been struggling. The Giants have totaled 2 or fewer runs in 6 of those setbacks, averaging 1.7 runs per game (RPG) during the span, with 6 of those runs coming in the series opener Friday.

Rays at Giants projected starters

RHP Ryan Pepiot vs. RHP Logan Webb

Pepiot (8-9, 3.86 ERA) makes his 26th start. He has a 1.18 WHIP, 3.1 BB/9 and 8.7 K/9 through 142 1/3 innings.

  • Last start: Win, 6 1/3 IP, 4 ER, 5 H (2 HR), 2 BB, 4 K in 7-4 road victory Monday vs. Athletics
  • Last 7 starts: 2-3, 5.18 ERA (40 IP, 23 ER), 16 BB, 37 K, 1.25 WHIP
  • 2025 road stats: 3-5, 4.34 ERA (64 1/3 IP, 31 ER), 9 HR, 25 BB, 54 K, 1.23 WHIP in 12 starts
  • Career vs. Giants: 0-1, 6.75 ERA (8 IP, 6 ER), 4 HR, 2 BB, 9 K, 1.13 WHIP, 10.1 K/9 in 2 appearances (1 start)

Webb (10-9, 3.34 ERA) makes his 26th start. He has a 1.26 WHIP, 2.1 BB/9 and 9.8 K/9 through 153 2/3 innings.

  • Last start: Loss, 6 1/3 IP, 4 ER, 8 H (1 HR), 1 BB, 3 K in 4-1 home loss Monday vs. San Diego Padres
  • Last 7 starts: 3-3, 5.40 ERA (40 IP, 24 ER), 11 BB, 41 K, 1.58 WHIP
  • 2025 home stats: 5-3, 3.01 ERA (80 2/3 IP, 27 ER), 6 HR, 17 BB, 87 K, 1.24 WHIP in 13 starts
  • Career vs. Rays (1 start): Win, 7 IP, 1 ER, 6 H, 1 BB, 4 K in 11-2 road win April 13, 2024

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Rays at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:07 a.m. ET.

  • Moneyline (ML): Rays +140 (bet $100 to win $140) | Giants -170 (bet $170 to win $100)
  • Run line (RL)/Against the spread (ATS): Rays +1.5 (-165) | Giants -1.5 (+135)
  • Over/Under (O/U): 7.5 (O: -118 | U: -102)

Rays at Giants picks and predictions

Prediction

Rays 6, Giants 3

Moneyline

The RAYS (+140) are a solid play as moderate underdogs with Pepiot on the hill. The Giants just haven't been able to consistently plate runs, and that isn't likely to change against the Tampa Bay right-hander, who has pitched well on the road.

The Giants could potentially be aided by the wind, with a wind blowing 9-11 MPH to the left-center field power alley, but the Rays will also be aided, too.

Run line/Against the spread

If you're a bit more conservative, the RAYS +1.5 (-165) is not a bad play if you need some insurance, and you just cannot trust Tampa Bay straight up for some reason.

The Giants are home, but they just cannot manage to cobble together any consistent offense.

Over/Under

OVER 7.5 (-118) is worth playing in Sunday's series finale.

The Giants might have difficulty scoring runs lately, but they've allowed 4 or more runs in 6 of the past 7 games during the losing skid. San Francisco has allowed 5.8 runs per game during the losing streak.

For the Rays, they've cashed high in 5 of the past 7 games, going for 4.8 RPG in the past 5 outings, while allowing 4 or more runs in 5 of the previous 7 contests.

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This article originally appeared on Sportsbook Wire: Tampa Bay Rays at San Francisco Giants odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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