The No. 21 Iowa State Cyclones kick off their 2025 season against the Big 12 Conference rival Kansas State Wildcats in a Week 0 matchup in Ireland on Saturday, Aug. 23. Iowa State shared the regular-season Big 12 championship, while Kansas State shared eighth-place in the conference with West Virginia. The Wildcats (5-4, 9-4), who were 2-1 against ranked opponents a year ago, had a plus-97 point differential. The Cyclones (11-3, 7-2), who were 9-2 against unranked foes, were plus-114 in point differential.

Kickoff is set for noon ET at Aviva Stadium in Dublin. Iowa State leads the all-time series 54-50-4, including a 29-21 win last season. The Wildcats are 3-point favorites in the latest Iowa State vs. Kansas State odds, while the over/under for total points scored is 49.5. Before mak

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