TOPLINE:

Isotretinoin was associated with slower growth rates in adolescents with acne but did not affect final adult height compared with antibiotics, a study found.

METHODOLOGY:

Researchers conducted a retrospective cohort study of 1406 patients with acne vulgaris (41% women; median age, 14.65 years; 85.4% White individuals) between 2005-2021 from the Rochester Epidemiology Project.

Patients received either isotretinoin for at least 3 months (n = 227) or oral antibiotics (n = 1179) before age 15, matched by sex and age at the time medication was initiated.

The primary outcome was final height recorded at age 18; secondary outcomes included pre- and post-medication initiation height velocity and change in height velocity.

Patients in the isotretinoin group received a median cumulati

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