TOPLINE:

Women with polycystic ovary syndrome (PCOS) who received metformin during pregnancy experienced a reduced rate of maternal infections, particularly viral infections. However, offsprings who were exposed to metformin in utero faced a high long-term risk for allergies and eczema.

METHODOLOGY:

Researchers in Norway conducted post hoc analyses of two randomised controlled trials and one follow-up study to examine immunologic effects of metformin in pregnant women with PCOS and in offsprings exposed to the medication in utero.

They analysed the data of 634 pregnant women with PCOS who had been randomly assigned to receive either metformin (n = 316; median age, 30 years) or placebo (n = 332; median age, 30 years) from the first trimester to delivery.

The effect of metformin exp

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