If you remember when Donna Karan was nouveau instead of “vintage” and are slathering on moisturizer to no avail, consider swapping your creamiest salve for something runnier. The best serums for mature skin can effectively target multiple signs of aging in a single swipe. “Think of serums as lightweight products with very small particle sizes,” says Dr. Erum Ilyas , MD, a board-certified dermatologist in Pennsylvania. “They do not have the thickness or weight of a lotion or a cream and can penetrate the skin more effectively.” She explains that the best facial serums for older skin have concentrated active ingredients targeting specific concerns, such as anti-aging and hydration. “As we get older— especially closer to menopause and post-menopause—your skin will simply not hold onto moi

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