A series win will be on the line when the Toronto Blue Jays battle the Pittsburgh Pirates in an interleague matchup on Wednesday afternoon. Toronto earned a 7-3 win on Tuesday, after Pittsburgh registered a 5-2 win in Monday's opener. The Blue Jays (74-53), who lead the American League East division, are 32-32 on the road this season. The Pirates (53-74), who are fifth in the National League Central, are 35-30 on their home field in 2025. Blue Jays first baseman Vladimir Guerrero Jr . missed Tuesday's game with left hamstring inflammation, and is listed as day-to-day.

First pitch from PNC Park in Pittsburgh is set for 12:35 p.m. ET. The Blue Jays have won eight of the past 10 meetings with the Pirates. Toronto is a -152 favorite on the money line (risk $152 to win $100) in the lates

See Full Page