A multiple-fatality tour bus crash early Friday afternoon on the New York State Thruway (Interstate 90) closed all lanes in both directions near the Western New York accident scene.

The tragedy involving the eastbound bus occurred between Exit 48A ( Pembroke /New York state Route 77) and Exit 49 (Depew/Lockport/NY Route 78), near mile marker 403.0, state police said. The location in the Genesee County town of Pembroke is midway between Rochester and Buffalo.

Eastbound traffic is being diverted from the toll road at Exit 49.

Westbound traffic was being diverted off the Thruway at Exit 48A, but those lanes have reopened, the New York State Thruway Authority tweeted at 5:08 p.m.

"Drivers should expect significant delays and are encouraged to seek alternate routes until further notice,

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