Research led by the Institute for Glial Sciences at Case Western Reserve University has identified a transcription factor that can keep glial cells in an immature state, preventing them from repairing the damage to myelin sheaths that characterizes multiple sclerosis (MS). In a study published today in Cell , the research team reports that inhibiting this molecular “brake” in mice can promote myelin regeneration.

“MS is a progressive disease that gets worse over time, and patients still lack therapies that can restore the myelin they’ve lost,” said Paul J. Tesar, PhD, director of the Institute for Glial Sciences and professor of innovative therapeutics at Case Western’s School of Medicine. “We believe these new insights will help deliver on the promise of regenerative therapies th

See Full Page