The Week 1 college football schedule brings dozens of intriguing matchups that will shape the early College Football Playoff picture. Games run from Thursday through Monday, highlighted by three ranked matchups involving top-10 teams with Texas vs. Ohio State (-1.5), LSU vs. Clemson (-3.5) and Notre Dame vs. Miami (+2.5). Those college football spreads are all within a touchdown, but there are also some giants numbers on the Week 1 college football odds board as some teams are starting out with easier opponents.

Indiana is a 23.5-point favorite over Old Dominion, per the Week 1 college football spreads, while Texas A&M is favored by 23.5 points over UTSA. Those are among a handful of games with Week 1 college football spreads of at least 20 points. Making college football predictions for

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