By Amy Tennery

NEW YORK (Reuters) -Sixth seed Ben Shelton retired injured from his U.S. Open third-round match while locked at two sets all against Frenchman Adrian Mannarino on Friday in a massive blow to American hopes of ending their 22-year wait for a men’s Grand Slam champion.

Shelton grabbed at his left shoulder and winced in pain after hitting a forehand shot early in the fourth set in a tight clash on Louis Armstrong Stadium and pinched at the spot as he prepared to receive a serve from Mannarino in the second game.

“I just did something to my shoulder I don’t know what it is. I’m in a lot of pain,” Shelton said to his father and coach, Bryan Shelton, before taking a medical timeout midway through the second game in the fourth set.

Shelton later added to his father that it was

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