Penn State football head coach James Franklin smiles during a practice session outside Holuba Hall on Saturday, August 2, 2025, in State College.

The Penn State Nittany Lions open their season with a home game against the Nevada Wolf Pack on Saturday afternoon. The Nittany Lions come in as the third-ranked team in the country and are thinking this could finally be their year.

Drew Allar returns at quarterback, and he is joined by the two-headed monster of Kaytron Allen and Nick Singleton at running back. It is one of the best backfields in the country, and they are looking to impose their will on the Wolf Pack on Saturday afternoon.

If you're looking to get back in the swing of football season and need some betting advice for Friday's matchup in State College, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream Penn State vs. Nevada

Penn State vs. Nevada game odds:

All college football odds via BetMGM

  • Spread: Penn State -43.5 (-105), Nevada +43.5 (-115)
  • Money Line: Penn State N/A, Nevada N/A
  • Over-Under: Over 54.5 (-110), Under 54.5 (-110)

Penn State vs. Nevada prediction, pick:

Penn State has national title aspirations this season after falling short in the semifinals last season. They have one of the most experienced teams in the country, and many think they are the top team in the nation. They will be looking to make a statement with their game on Saturday, but the line is high. The Wolf Pack is coming off a three-win season and is just trying to keep things close. It isn't going to be close, but 43.5 is a huge line. The Nittany Lions win easily, but don't cover.

Prediction: Penn State 42, Nevada 7

Best Bet: Nevada +43.5, Under 54.5

Penn State vs. Nevada channel, start time, streaming:

Time: 3:30 p.m. ET

TV Channel: CBS

Live Stream: Paramount+

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Penn State vs. Nevada: Week 1 College Football Betting Odds, Prediction, Pick

Reporting by Adam Childs, College Sports Wire / College Sports Wire

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