The No. 4 Clemson Tigers are set to host the No. 9 LSU Tigers on Saturday in one of the most highly-anticipated matchups on the Week 1 college football schedule. Clemson, led by quarterback Cade Klubnik , finished the 2024 season 10-4, earning a trip to the College Football Playoff. LSU, entering its fourth season under head coach Brian Kelly, comes off a 9-4 campaign and is led by veteran quarterback Garrett Nussmeier . Both quarterbacks are widely considered to be among the top Heisman Trophy contenders in the country.

Kickoff is set for 7:30 p.m. ET at Memorial Stadium in Clemson, S.C.. Clemson is a 4-point favorite in the latest Clemson vs. LSU odds, while the over/under for total points scored is 56.5. Before making any LSU vs. Clemson picks, be sure to see what SportsLine e

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