Virginia Tech and No. 13 South Carolina will meet up for the final ACC-SEC matchup of the Week 1 college football schedule on Sunday afternoon. The Hokies will be looking for a strong start after finishing 2024 with a 6-7 record, going 2-4 on the road. Meanwhile, the Gamecocks went 9-4 in 2024 with a 4-1 road record, but fell short of a playoff berth.

Kickoff from Mercedes-Benz Stadium in Atlanta is set for 3 p.m. ET. The Gamecocks are 7.5-point favorites in the latest Virginia Tech vs. South Carolina odds from SportsLine consensus, while the over/under for total points scored is 51.5. The Gamecocks are -296 money line favorites, while the Hokies are +237 underdogs. Before making any South Carolina vs. Virginia Tech picks, make sure you check out the picks from SportsLine's proven com

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