Week 1 of the 2025 college football season continues on Sunday with two matchups, including a matinee SEC vs. ACC showdown as No. 13 South Carolina takes on Virginia Tech in Atlanta at 3 p.m. ET in one of the 2025 Aflac Kickoff Games. The Gamecocks finished just outside the College Football Playoff picture last season and return Heisman candidate LaNorris Sellers at quarterback. Virginia Tech, meanwhile, finished 6-7 last year and is looking to take a big step forward in the fourth full season for head coach Brent Pry. The Gamecocks are 7.5-point favorites in the latest South Carolina vs. Virginia Tech odds for college football betting , with the over/under at 51.5 in the latest college football odds. Many major sportsbooks have profit boosts that can be used on this game.

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