Will Isaac Guerendo play for the San Francisco 49ers in 2025? Will Isaac Guerendo be healthy enough to play in Week 1? John breaks down the latest Isaac Guerendo injury news for fantasy football.

San Francisco 49ers running back Isaac Guerendo (shoulder) had a promising rookie campaign in 2024, playing in relief of starting running back Christian McCaffrey . In the freshman's first game playing over 50 percent of the snaps, he scored 19.20 PPR fantasy points.

He played just three more games with over half the offensive snaps, and racked up 26.8, 11.5, and 13.9 PPR points. Though these were impressive overall numbers, he also suffered from injuries later in the season. He's also currently dealing with a shoulder issue.

Guerendo clearly has a ton of potential, but it's questionable if

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