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DETROIT — Clay Holmes picked the wrong time to miss the strike zone with a few pitches.

Already, the Mets right-hander had walked Colt Keith in Wednesday’s fifth inning.

But Holmes retired Gleyber Torres for the second out and was in position to escape the inning with the score 1-1, then perhaps pitch into the sixth.

A second walk in the inning, to Kerry Carpenter, changed the script. Holmes was removed, and Gregory Soto unloaded a wild pitch before allowing a single to Riley Greene for two runs in the 6-2 loss to the Tigers at Comerica Park.

Clay Holmes of the New York Mets throws a first-inning

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