The James Madison Dukes (1-0) tangle with the Louisville Cardinals (1-0) in a Friday-night Week 2 contest. The tussle at L&N Federal Credit Union Stadium in Louisville will kick off at 7 p.m. ET (ESPN2). Let's analyze BetMGM Sportsbook's NCAA football odds around the James Madison vs. Louisville odds and make our expert college football picks and predictions for the best bets.

James Madison rambled for 313 rushing yards in a season-opening 45-10 victory over FCS Weber State Saturday. That output marked a program-best since JMU joined FBS ranks in 2022. It was in that first FBS season when the Dukes had their only meeting with these Cardinals: UL defeated JMU 34-10 on Nov. 5, 2022.

Louisville, meanwhile, was busy throwing the football in its first game. The Cardinals attempt

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