There’s a delightful alchemy to “Twinless,” the sophomore film from writer/director/co-star James Sweeney (“Straight Up”). Billed as a dark comedy about two strangers who trauma bond over the deaths of each of their twin brothers, it often sidesteps its morose premise — hilariously and diabolically so. It’s an unsparing examination of loneliness and grief, thanks to a devastating knockout dual performance by co-star Dylan O’Brien. It’s also one of the funniest movies of the year, unabashed in its morbid humor and scathing dialogue.

It’s chameleonlike, cleverly shifting between queer rom-com, affecting drama and Hitchcockian thriller. And once you begin to realize that things aren’t what they seem, it always leaves you wondering just what’s coming next.

“Twinless” opens with a car crash,

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