San Francisco 49ers running back Christian McCaffrey will play against the Seattle Seahawks in Week 1, according to Adam Schefter. His status had been up in the air since being added to the injury report earlier this week with a calf injury.

McCaffrey was listed as questionable on the Week 1 injury report giving him a 50/50 chance to suit up. He barely practiced on Friday but said he was feeling great in the locker room. Then he participated in the walkthrough Saturday and was trending toward being in the lineup. The 49ers RB only appeared in four games in 2024 with multiple injuries.

To compound matters for the season opener, two other 49ers backs are on the injury report; Isaac Guerendo and Jordan James.

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