The San Francisco 49ers will be at full strength for their Week 1 matchup against the Seattle Seahawks on Sunday at Lumen Field.

After popping up on Thursday's injury report with a calf injury , star running back Christian McCaffrey will play in San Francisco's 2025 NFL season-opening matchup against Seattle, ESPN's Adam Schefter reported Sunday morning, citing a source.

49ers RB Christian McCaffrey, who was added to the injury report Thursday with a calf issue, will play today vs. the Seahawks. “He’s good to go,” said one source. pic.twitter.com/K58t9DFlhq — Adam Schefter (@AdamSchefter) September 7, 2025

McCaffrey's addition to the injury report earlier this week sent shockwaves throughout the 49ers' fan base after the star running back missed the first eight games of the 2024

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