The New Orleans Saints will host the Arizona Cardinals in an NFL Week 1 NFC showdown. The Cardinals are looking to get off to a hot start after they finished 2024 with a 8-9 record and missed the playoffs for a third straight year. Meanwhile, the Saints finished at the bottom of the NFC South with a 5-12 record and hope to turn things around with former Eagles offensive coordinator Kellen Moore as their new head coach. Cardinals quarterback Kyler Murray (illness) has been added to the injury report, but is expected to start against New Orleans.

Kickoff from Caesars Superdome in New Orleans is set for 1 p.m. ET on CBS and Paramount+. Arizona is a 6.5-point favorite in the latest Cardinals vs. Saints odds from SportsLine consensus, while the over/under for total points scored is 43. Bef

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