The Iowa State Cyclones (3-0) and Arkansas State Red Wolves (1-1) tangle in a Saturday contest in Jonesboro, Arkansas. The opening kick-off at Centennial Bank Stadium will be at 4 p.m. ET (ESPN2). Let's analyze BetMGM Sportsbook's NCAA football odds around the Iowa State vs. Arkansas State odds and make our expert college football picks and predictions for the best bets.

No. 14 Iowa State is 3-0 largely thanks to allowing just 41 total points so far. ISU is fresh off a rivalry win over the Iowa Hawkeyes (push on a -3 with a 16-13 victory). The Cyclones also played the Red Wolves after last year's Iowa game and ISU won that game 52-7 covering a -20.5. That 2024 meeting was the first between Iowa State and ASU.

Arkansas State downed the Southeast Missouri State Redhawks 42-24 in

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