The Houston Cougars (2-0) will host the Colorado Buffaloes (1-1) to open Big 12 play in a Week 3 college football matchup on Friday. Houston has outscored its opponents 62-9 to open the season, with decisive victories over SF Austin and Rice after back-to-back 4-8 seasons. Colorado is coming off a 31-7 victory over Delaware after falling to Georgia Tech in its opener as the Deion Sanders era continues without his son, Shedeur, at quarterback. The Buffaloes used a three-quarterback rotation last Saturday, and they could play multiple quarterbacks on Friday.

Kickoff from TDECU Stadium in Houston, Texas is set for 7:30 p.m. ET on Friday. Houston is a 5-point favorite in the latest Houston vs. Colorado odds from SportsLine consensus, while the over/under for total points scored is 45. Before

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