The San Francisco 49ers will take on the New Orleans Saints in and NFC showdown during Week 2 on Sunday at Caesars Superdome. Kickoff is 1:00 p.m. ET.

San Francisco enters the matchup with major injury storylines. Quarterback Brock Purdy is sidelined by toe and shoulder issues, putting Mac Jones under center. Tight end George Kittle landed on injured reserve with a hamstring injury. Left tackle Trent Williams and receiver Jauan Jennings have both missed practice time, which could further test the offense. Running back Christian McCaffrey, however, returned as a full participant after a rest day, and Nick Bosa is back in action after managing his workload earlier in the week. The 49ers’ ability to protect Jones and maintain their run-game rhythm will hinge on how this unit’s health devel

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