The 2025 NFL season rolls on with a full schedule of 13 games on Sunday, a dozen of which comprise the 'main slate' on many DFS sites. The Sunday Week 2 NFL DFS player pool is loaded with star power, featuring elite talents such as quarterback Joe Burrow and his top target Ja'Marr Chase, dynamic wideout CeeDee Lamb, and dual-threat running back Christian McCaffrey. Fantasy players will also have to weigh the upside of explosive playmakers like Lamar Jackson, power backs Derrick Henry and Saquon Barkley, and MVP-caliber quarterbacks Patrick Mahomes and Jalen Hurts.

Should you target Burrow and Chase when building NFL DFS lineups and NFL DFS stacks? Or should you build your NFL DFS strategy around a star running back like Barkley, Henry, or McCaffrey? Before locking in any NFL DFS picks on

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