AFC South meets NFC South as the Houston Texans host the Tampa Bay Buccaneers on Monday Night Football in NFL Week 2. The Texans are looking for their first win of the 2025 NFL season after being held without a touchdown in a 14-9 Week 1 loss to the Los Angeles Rams. Meanwhile, the Buccaneers enter Week 2 following a nail-biter against the Atlanta Falcons that ended with a 23-20 victory.

Kickoff from NRG Stadium is set for 7 p.m. ET. Houston is a 2.5-point favorite in the latest Buccaneers vs. Texans odds, and the over/under for total points scored is 42.5. Before making any Texans vs. Buccaneers picks, make sure you check out the NFL picks from the SportsLine Projection Model.

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