The Indianapolis Colts host the Denver Broncos in NFL Week 2 action.

The Colts will be short-handed on defense, missing two cornerbacks. Denver's defense was the NFL's best in Week 1.

The Indianapolis Colts host the Denver Broncos in NFL Week 2 action, both teams coming off opening victories. The Colts will be short-handed on defense, missing two cornerbacks and perhaps a pass rusher. Denver's defense was the NFL's best in Week 1.

We will have live score updates and highlights throughout, so please remember to refresh.

What time does Indianapolis Colts-Denver Broncos NFL game start tonight, Sunday, Sept. 14, 2025? When is Broncos-Colts football game today?

The Denver Broncos and Indianapolis Colts will play at 4:05 p.m. ET Sunday, Sept. 14, 2025. Watch Broncos-Colts NF

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