Two AFC teams looking to move to 2-0 face off in NFL Week 2 as the Indianapolis Colts host the Denver Broncos . The Colts, who finished the 2024 season 8-9, have gotten the Daniel Jones era off to a hot start thanks to a 33-8 upset against the Miami Dolphins in Week 1. The Broncos finished last season 10-7 and had a Week 1 victory of their own, taking down the Tennessee Titans , 20-12.

Kickoff from Lucas Oil Stadium is set for 4:05 p.m. ET on CBS and Paramount+ . Denver is a 2.5-point favorite in the latest Broncos vs. Colts odds from SportsLine consensus, while the over/under for total points scored is 43.5. The Broncos are -124 money line favorites (risk $124 to win $100), while the Colts are +104 underdogs. Before making any Colts vs. Broncos picks, make sure you check out

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