Key Takeaways

Psilocybin might produce lasting relief for depressionTwo-thirds of participants in a small-scale clinical trial said they were in complete remission from depression five years laterInterviews suggest the treatment helped patients see their depression as situational and manageable

MONDAY, Sept. 15, 2025 (HealthDay News) — The benefits of psilocybin treatment for depression might last as long as five years for some, a new study says.

Two-thirds of participants in an early psilocybin clinical trial remained in complete remission from their depression when researchers checked in on them five years later, according to results published in the Journal of Psychedelic Studies .

“Five years later, most people continued to view this treatment as safe, meaningful, important and

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