Conference play across college football kicks into high gear within the Big Ten, SEC and Big 12 in Week 4 and we've crunched the numbers with predictions and final picks for this weekend's biggest games. Three nationally ranked matchups highlight the docket -- No. 9 Illinois vs. No. 19 Indiana , No. 22 Auburn vs. No. 11 Oklahoma and No. 17 Texas Tech vs. No. 16 Utah -- along with No. 21 Michigan vs. Nebraska separating early contenders from pretenders at the top of the league standings.

Matt Rhule is 0-6 against top 25 teams with the Huskers and has an opportunity on Saturday at home to post Nebraska's first win over Michigan since 2013. Unbeatens Texas Tech and Utah square off in Salt Lake City, a battle featuring two of the nation's most explosive offenses.

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