The Indianapolis Colts will face off against the Tennessee Titans in a crucial Week 3 NFL matchup at Nissan Stadium on Sunday, September 21, 2025. Both teams are looking to make an impact early in the season, and this game could be pivotal in shaping their standings in the AFC. The Colts, with a 67% chance of victory according to Dimers’ predictive model, are favored to win the game, and they will look to leverage their strengths, including standout running back Jonathan Taylor, to continue their strong start. The Titans, however, are coming off a tough battle and will aim to pull off an upset in front of their home crowd.

The Colts enter this game with the advantage, thanks to their well-rounded team led by quarterback Daniel Jones, who has been showing steady growth since joining the sq

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