CAMBRIDGE, Mass. — Biogen on Tuesday held a ceremonial groundbreaking of its 16-story headquarters in Kendall Square, ushering in the latest phase of the neighborhood’s transformation from “Nowhere Square” to what its backers like to call “the most innovative square mile on the planet.”

Nobel laureates Walter Gilbert and Phillip A. Sharp cofounded Biogen in 1978 and, four years later,set up shop in a warehouse on Binney Street. When the company moves into its 580,000-square-foot headquarters at 75 Broadway in 2028, Biogen will be celebrating its 50th anniversary.

“We are surrounded by global beacons of progress and ingenuity — companies that led us out of the pandemic , scientists who are cracking the code on diseases like Alzheimer’s and cancer, and startups destined to unlock an

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