Miami Dolphins at Buffalo Bills best prop bets for Thursday Night Football

Buffalo Bills running back James Cook (4) rushes for a touchdown against the New York Jets during the first half at MetLife Stadium in East Rutherford, New Jersey.

The Miami Dolphins (0-2) and the Buffalo Bills (2-0) meet for Thursday Night Football at Highmark Stadium in Orchard Park, New York. Kickoff is scheduled for 8:15 p.m. ET (Prime Video). Let's analyze BetMGM Sportsbook's Dolphins vs. Bills odds and tab the 5 best prop bets to win among SportsbookWire's expert NFL picks and predictions for Week 3.

The Dolphins played a much better game in Week 2 than they did in their opening effort. After getting drilled 33-8 by the Indianapolis Colts on the road in Week 1, failing to cover as a 1-point underdog, the Dolphins suffered a 33-27 loss to the New England Patriots at home last Sunday. While they lost, there were still some encouraging signs on offense. QB Tua Tagovailoa threw for 315 yards and 2 TDs in the loss to the Patriots, while WR Tyreek Hill had his first 40-plus yard catch since Week 1 of the 2024 season, finishing with 109 yards.

The Bills opened the campaign with a scintillating 41-40 comeback win over the Baltimore Ravens on Sunday Night Football in Week 1, while belting the New York Jets 30-10 on the road in Week 2, easily cashing as a 6-point favorite. RB James Cook ran for 132 yards and 2 TDs in the victory over New York. The defense was obviously much improved in the second game, too, while the offense continues to run roughshod over everybody.

The Dolphins might have to do without WR Jaylen Waddle, however, as he is listed as questionable due to a shoulder injury. TE Darren Waller (hip) is out, while CB Storm Duck (ankle) and S Ifeatu Melifonwu (calf) are also out. LB Chop Robinson (knee) carries a questionable tag, too, and he'd be a huge absence for the pass rush if he cannot go.

The Bills are in much better shape, health-wise, as LB Shaq Thompson (hamstring, hand) is questionable, with LB Matt Milano (pectoral) and DT Ed Oliver (ankle) out. All offensive players are healthy and ready to go. PK Matt Prater continues to fill in for the injured PK Tyler Bass.

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Best Dolphins at Bills prop bets

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 4:04 p.m. ET.

Bills QB Josh Allen OVER 233.5 PASSING YARDS (-115)

While the Bills ran the ball down the throats of the New York Jets last Sunday, and that figures to be a vital part of the Buffalo offense on Thursday, at first glance, this number appears to be super low. Take advantage.

While last season, on a Thursday night game in Miami, Allen was held to just 139 passing yards and a TD, that was a strange game which saw Tua exit early with a concussion. Buffalo built a big lead, and went with a mostly run-heavy offense. Allen also hurt his left hand in a game against Arizona the week prior, so he could have been limited.

In the rematch in Buffalo on Nov. 13, Allen was 25-of-39 for 235 yards, 3 TDs and 1 INT. He has thrown for at least 232 yards in each of his past 6 regular-season games at home, including 394 yards in the Week 1 win over the Ravens.

Bills RB James Cook ANYTIME TOUCHDOWN (-165)

While I am not thrilled about the high price tag, Cook is still a good bet to score a touchdown in Week 3.

Cook has 34 carries for 176 yards and 3 rushing scores through the first 2 games, including 132 yards, 2 scores and 6.3 yards per attempt against the Jets.

In last season's Thursday night game in South Florida, Cook went for 78 rushing yards and 2 TDs, while averaging 7.1 yards per carry. Look for Cook to be a hot knife through butter again in Week 3.

DOLPHINS AT BILLS: Odds, picks and predictions

Dolphins RB De'Von Achane OVER 5.5 RECEPTIONS MADE (-118)

Achane is worth backing in this one for several reasons. He has managed 11 receptions across the first 2 games, which is obviously nice. However, he should exceed his average of 5.5 receptions per game on Thursday night.

Waddle (shoulder) is questionable to play, and if he cannot go, that really will crush Tua's downfield threat. The Bills will likely double speedster WR Tyreek Hill, meaning a steady diet of short to intermediate routes.

Achane was extremely effective catching the football in Week 2 against the Patriots, piling up 8 receptions for a career-high 92 yards and a TD. In fact, he has TD receptions in each of his first 2 games. Miami is unlikely to shy away from one of the few things that is actually working.

Dolphins WR Tyreek Hill UNDER 66.5 PASSING YARDS (-110)

As mentioned above, Waddle is a question mark. Even if he plays, he is not 100 percent. That will leave Hill likely covered by CB Christian Benford and perhaps a helper. The targets could be fewer, the frustration level could be higher, and the separation non-existent.

Hill shined with 6 grabs for 109 yards against the Patriots in Week 2, but had just 4 receptions for 40 yards on 6 targets in Week 1 at Indianapolis in the first game. That's likely a lot more of what you should expect.

Last season, Hill had 3 receptions for just 24 yards on 6 targets in the Thursday night game in South Florida, and he has a very ordinary 55.4 receiving yards per game in the past 5 regular-season outings vs. Buffalo.

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Dolphins PK Riley Patterson OVER 5.5 POINTS (-105)

Patterson is holding down the fort in the Miami kicking game with Jason Sanders out due to injury.

While the Dolphins are likely going to take it on the chin, playing a Super Bowl contender in their place, while entering as a double-digit underdog, there is opportunity for Patterson to shine. If Miami scores, especially early on, it is likely to come off the foot of Patterson. I could easily see 2 field goals, just don't expect many point-after attempts.

Yep, that's 3 weeks in a row with kicker props!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Miami Dolphins at Buffalo Bills best prop bets for Thursday Night Football

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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