An AFC East clash will take place on 'Thursday Night Football' in Week 3 as the Miami Dolphins visit the Buffalo Bills . Miami (0-2) looked listless in its season opener, and while it played better in a Week 2 loss to New England, the team is still 0-2 for the first time since 2019. Meanwhile, Buffalo (2-0) had a miraculous comeback victory in Week 1 before easily handling the Jets on Sunday. Bills coach Sean McDermott is 9-0 all-time at home versus the Dolphins, including the playoffs.

Kickoff is at 8:15 p.m. ET from Highmark Stadium in Orchard Park, N.Y. Buffalo is the 12.5-point favorite in the latest Dolphins vs. Bills odds, making them the biggest favorite of the 2025 NFL season if the line holds. The over/under for total points is 50.5. Buffalo is a -909 favorite on the money li

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