LONDON — Frida Kahlo’s face is one of the best known in art, thanks to her bold and challenging self-portraits.

A lesser-seen self-depiction by the Mexican artist is going up for auction at Sotheby’s in what could be a record-setting sale.

With an estimated price of $40 million to $60 million, “El sueno (La cama)” — “The Dream (The Bed)” may surpass the top price for a work by any female artist when it goes under the hammer on Nov. 8. That record currently stands at $44.4 million, paid at Sotheby’s in 2014 for Georgia O’Keefe’s “Jimson Weed/White Flower No. 1.”

The highest price at auction for a Kahlo work is $34.9 million, paid in 2021 for “Diego and I,” depicting the artist and her husband, muralist Diego Rivera. Her paintings are reported to have sold privately for even more.

“It’s

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