One-time Guardians top pitching prospect Daniel Espino 's career has been impacted by injury setbacks, including multiple right shoulder surgeries. But the 24-year-old is set to complete a remarkable comeback this weekend in his journey defined by incredible perseverance.

Espino, who is ranked as the Guardians’ No. 29 prospect by MLB Pipeline, will open Triple-A Columbus’ game against Omaha on Saturday at Huntington Park. It will mark the right-hander’s first appearance since April 29, 2022 , when he was with Double-A Akron.

The outing, which will come in Columbus’ penultimate game of the season, figures to serve as a launching point for Espino -- who is among eight Guardians prospects slated to play in the Arizona Fall League , which begins on Oct. 6.

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