Michigan State's Aiden Chiles communicates with teammates before the snap against Youngstown State during the second quarter on Saturday, Sept. 13, 2025, at Spartan Stadium in East Lansing.

Talk about a nightcap! Saturday night gives us not only an intriguing conclusion but a Big Ten matchup of two squads that enter this game with perfect 3-0 records.

The Michigan State Spartans head out to Los Angeles to take on the USC Trojans in a Big Ten showdown that fans can tune into to finish off a perfect Week 4 of college football.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream USC vs. Michigan State

USC vs. Michigan State game odds

All college football odds via BetMGM

  • Spread: USC -18.5 (-110), Michigan State +18.5 (-110)
  • Money Line: USC -1000, Michigan State +625
  • Over-Under: Over 55.5 (-115), Under 55.5 (-105)

USC vs. Michigan State prediction, pick:

This game is going to tell us a lot about both of these teams. Michigan State's best win is against Boston College, while USC's best win is against Purdue. Neither stands out. What raises some eyebrows is how big the spread is. The Trojans beat Purdue by just 16 points last weekend, 33-17. Michigan State figures to be a better team than Purdue, right?

The Spartans' quarterback, Aidan Chiles, can cause some headaches with his raw athleticism. While he has taken eight sacks already, he has just one interception, while throwing for 656 yards and six touchdowns. He has the skills to keep Michigan State hanging around and lingering in this game.

Prediction: USC 30, Michigan State 21

Best Bet: Michigan State +18.5

USC vs. Michigan State channel, start time, streaming:

Time: 11 p.m. ET

TV Channel: FOX

Live Stream: FOX Sports App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: USC vs. Michigan State: Week 4 College Football Betting Odds, Prediction, Pick

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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