The Arizona Cardinals continue their 2025 NFL regular season schedule with an NFL Week 3 game against the San Francisco 49ers today.

The Cardinals (2-0) are coming off a 27-22 win against the Carolina Panthers in their NFL Week 2 game.

The 49ers (2-0) beat the New Orleans Saints in the second week of the season, 26-21.

The Cardinals won both games against the 49ers, an NFC West division rival, last season.

Follow our live updates of the game, which is being played at the 49ers' Levi's Stadium in Santa Clara, California, for the latest score, news, notes and analysis of the Week 3 NFL game on Sunday, Sept. 21. Expert MLB daily picks: Unique MLB betting insights only at USA TODAY How to watch: Arizona Cardinals vs San Francisco 49ers schedule, TV channel for NFL Week 3 gam

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