The Week 5 college football odds board is loaded with some of the more intriguing matchups of the season. Among the notable Week 5 college football lines, No. 3 Penn State is -3.5 against No. 6 Oregon, No. 5 Georgia is -3 against No. 17 Alabama and No. 13 Ole Miss is -2.5 against No. 4 LSU.

How should you make college football picks for those games, and what are the best spread, total and money-line picks to include in college football best bets? Before locking in any Week 5 college football picks, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall .

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famous sports betting newsletter. He has also won various handicapping titles and also is working on several book project

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